The immense amount of aluminum in the Earth’s crust and the increasing acidification of the environment results in a growing exposure to this element. Development of modern and sensitive research techniques, including analytical methods of tracing aluminum in tissues, have helped realize that exposure to aluminum compounds increases its concentration in skin, lung tissues, liver, spleen, bones, teeth and neural tissues. Literature on the subject shows the interaction of aluminum and fluorine during the process of absorption, which may suggest certain protective measures against their toxic effects.

The aim of this study was to examine the influence of the exposure to AlCl₃ and NaF in drinking water on the concentration of aluminum in the serum and bones of rats. The rats were divided into the following groups: I – females, receiving 100 ppm fluoride ions for one month; II – females receiving fluorine (100 ppm) and 300 ppm of aluminum ions alternately every second day for one month, III – females receiving 100 ppm F^- for four months; IV – females receiving fluorine and aluminum every second day (100ppm and 300ppm, respectively) for four months; groups IA, IIA, IIIA, IVA were male and were treated indentically. Relevant control groups were assigned for both males and females; controls were given only distilled water ( groups K_1, K2, K₃, K₄ ). After the experiment the animals were terminated after being given general anaesthetic. Their blood was sampled directly from their hearts and bone samples came from their right thighs. The aluminum concentrations in the adequately prepared serum and bone samples were determined with the ICP AES method. The results were analysed with Statistica 6 software.

The mean concentrations of aluminum in the serum and bones of the rats receiving only AlCl₃ were 0,2 µg/mL and 42,54 µg/mg in females, and 0,22 µg/mL and 29,215 µg/mg in males (after a one month exposure), and respectively 0,14 µg/mL and 43,32 µg/mg in females, and 0,10 µg/mL and 28,10 µg/mg males after a four-month-long exposure.

For the groups receiving fluorine and aluminum for one month the values were 0,27 µg/mL and 46,26 µg/mg for females, and 0.2 µg/ml and 26,37 µg/mg for males. Longer exposure to both the elements resulted in a slight decrease in aluminum concetration to 0,22 µg/Ml in serum and 40,75 µg/mg in the bones of females; and 0,18 µg/mL and 26,40 µg/mg in males. Athough the concentration of aluminum in bones was higher in females compared with males, the difference was not statistically significant.

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