Pregnancy and the periparturient period are physiological states that are known to modify metabolism in the maternal organism. In this period, many organs as well as the nervous and endocrine systems are highly mobilised in order to provide optimal conditions for embryonic development. During pregnancy, maternal tissues are involved in providing energy for reproduction processes potentially influencing the concentrations of metabolites in the blood, which are also affected by several other factors such as breed, age, energy balance, fetal growth or season. On the other hand the etiology of osteopenia and osteoporosis in goat’s infants has not been fully explained. Chronic deficiency of minerals can decrease the formation of the osseous matrix and tissue mineralization. Ketosis, which can occur during pregnancy, is an additional factor that also intensifies the resorption of the osseous tissue through the activation of osteoclasts. This may lead to changes in the concentration of biogenic elements in this tissue such as calcium and magnesium but also fluorine. Fluorine is considered to be one of the strongest stimulators of osseous tissue formation.
Taking these facts into consideration we aimed to examine the effect of the periparturient period on plasma fluoride concentrations in goats (Capra hircus); 75% genotype of the Polish Noble White, aged 2−3 years and weighing 45−55 kg. Blood samples were taken from 12 goats during the periparturient period (4 and 1 weeks before and 2, 10 and 30 days after delivery), and from 10 nonpregnant goats. The fluoride concentration in plasma was determined with the potentiometric method.
Pregnat goats were observed to have a statistically significant lower concentration of fluorine in plasma compared with the nonpregnant. Moreover the concentration of fluorides in the plasma decreased after delivery. 

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