Pneumocystis pneumonia (PCP), caused by Pneumocystis carinii, is the opportunistic infection in people with weakened immune system. Available therapies (for example those using pentamidine) have many adverse effects and are limited by toxicity. Therefore we have designed and synthesized new pentamidine analogs with amino groups (Fig. 1).

Fig. 1. Synthesized compounds.

We analyzed the solid state ¹³C CP/MAS NMR spectra of obtained compounds and discussed their conformations, intermolecular interactions and polymorphism.

Comparison of melting points between d(CGCGAATTCGCG)₂ DNA fragment and its complex with 1,5-bis[(4-amidinophenyl)amino]-3-oxapentane dihydrochloride (2) proves that this compound could bind to minor grove of DNA.

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