Molecular imprinting is a tool by which selective recognition sites can be created in a polymer during the synthetic procedure. The monomers and the cross-linkers form a three-dimensional matrix around chosen molecule named a template. After removal of the template molecules, the cavities created in polymer matrix are complementary both in terms of shape and functionality to the template. New molecularly imprinted polymers (MIP) are being developed for solid phase extraction (SPE), chromatographic separation, organic syntheses as protecting groups and catalysts. Many parameters are important for production of MIPs with good recognition ability. For example, crucial role plays properties of: the monomers, the porogens, the cross-linkers, and also the polymerization procedures.

The aim of this presentation is to show achievements in synthesis, physicochemical analysis, and theoretical studies on molecularly imprinted materials. Our laboratory is engaged in searching for selective materials which could be used in analysis of 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) and its metabolites (1-3). Synthesis - non-covalent approach was applied to form MIPs by the radical bulk polymerization with the different functional monomers, the cross-linkers, and the porogens. First evaluation – the imprinting factors (IF) were calculated as the relationship between the binding capacity of MIP and its non-imprinted counterpart. Analysis of adsorption parameters - the best imprinted resins were analyzed using Scatchard equation, scanning electron microscopy, spectroscopic methods. Analysis of recognition mode - the compounds of similar structures were tested in non-competitive binding experiments. Theoretical analysis - it is not easy task to model real polymer system, but it is possible to work up step by step procedure for evaluation of the polymer matrix. Steps - the most promising monomer was chosen on the basis of the energies of prepolymerization complexes; the structure of the most stable complex was used to simulate the cavity in the polymer matrix. In the computations, solvent effects were approximated by the distance dependent dielectric constants ε r_ij.

¹P. Luliński, D. Maciejewska. Mater. Sci. Eng. C. 31, 281-289, 2011.

²T. Żołek, P. Luliński, D. Maciejewska. Anal. Chim. Acta. 693, 121-129, 2011.

³M. Dana, P. Luliński, D. Maciejewska. Molecules 16, 3826-3844, 2011.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/25452 must be provided.

1. Synthesis and characterization of 3-indolylmethanol imprinted polymers
2. Separation of octopamine on 2-amino-1-phenylethanol imprinted polymer - theoretical and experimental investigation
3. Synthesis and anticancer properties of coumarin gallates
4. Microwave-assisted synthesis and antimicrobial activity of O-alkylamino derivatives of benzofurancarboxylic acids
5. MICROWAVE-ASSISTED SYNTHESES OF SUBSTITUTED COUMARINS
6. THEORETICAL ANALYSIS OF BIOLOGICALY ACTIVE CONFORMATIONS OF SOME BIS-AMIDINES
7. 3,3'-DIINDOLYLMETHANES - SYNTESIS AND STRUCTURAL ANALYSIS
8. AMINO ANALOGUES OF DNA MINOR GROOVE BINDER PENTAMIDINE - SYNTHESIS AND STRUCTURAL STUDIES