3,3'-Diindolylmethane is a promising cancer chemopreventive agent derived from Brassica food plants, and its mode of action is widely examined. Therefore we have chosen it as a template structure in our search for new compounds with better pharmacological profile.

In course of our studies we are interested in optimization of synthetic procedure leading to 5,5'- or 6,6'-disubstituted bis-indoles (Fig. 1) [1].

Fig. 1. Intermediates in the synthesis of bis-indoles.

The ¹H and ¹³C NMR spectra of reagents in solution show standard resonances and enabled us to confirm the synthetic pathway.

The ¹³C CP/MAS NMR spectra of products represent various signal patterns. This could have been caused by:

- the presence of two energetically similar conformers in the solid state

- the different packing mode of both indole rings in one conformer

- the presence of only one conformer with magnetically equivalent C atoms in both indole rings

1. D. Maciejewska, M. Niemyjska, I. Wolska, M. Włostowski, M. Rasztawicka in Z. Naturforsch. 59b, 1137-1142, (2004).

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/6306 must be provided.

1. Synthesis and characterization of 3-indolylmethanol imprinted polymers
2. Separation of octopamine on 2-amino-1-phenylethanol imprinted polymer - theoretical and experimental investigation
3. Synthesis and anticancer properties of coumarin gallates
4. Microwave-assisted synthesis and antimicrobial activity of O-alkylamino derivatives of benzofurancarboxylic acids
5. The molecularly imprinted polymers as selective  sorbents to pharmaceutical analyses
6. MICROWAVE-ASSISTED SYNTHESES OF SUBSTITUTED COUMARINS
7. THEORETICAL ANALYSIS OF BIOLOGICALY ACTIVE CONFORMATIONS OF SOME BIS-AMIDINES
8. AMINO ANALOGUES OF DNA MINOR GROOVE BINDER PENTAMIDINE - SYNTHESIS AND STRUCTURAL STUDIES