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Influence of Bioimplants on Immune Response

Natalya V. Shishkova 2Lyudmila I. Donchenko 1Sergey A. Tkachenko 3

1. Donetsk State Medicine University, Donetsk Institute of Traumatology & Orthopedics, 72, R.Luxemburg St., Donetsk 340114, Ukraine
2. National Academy of Sciences of Ukraine, A.Galkin Donetsk Institute for Physics & Technology (DonPTI NASU), Roza Luxemburg 72, Donetsk 83114, Ukraine
3. Kiev State Medicine University (KSMU), Kyiv Kiev, Ukraine

Abstract

The development and processing of some kind new implantable biological materials is impossible without understanding of processes taking place in organism after implantation and methods of their estimation.
In this work we have studied the peculiarities of immune response at application of auto- and allo-implants as the natural biological implantable materials for Achilles' tendon for rabbits of Chinchilla breed. The comparative estimation was realized in dynamics of experiment.
It was established that peculiarity of immune response on biological implant of allotransplant is characterized by more expressed inhibition of lymphoid chain of immune system for the early post-surgery period than on auto-plastics and by normalization of immune system indexes for the later terms. This allows us to recommend the given allo-transplant for reconstructive surgery at the tendon injuries.

 

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Related papers

Presentation: poster at E-MRS Fall Meeting 2003, Symposium E, by Natalya V. Shishkova
See On-line Journal of E-MRS Fall Meeting 2003

Submitted: 2003-05-08 10:54
Revised:   2009-06-08 12:55