A study was undertaken to evaluate changes in plasma cortisole level, oxidative stress indices and biochemical parameters related to liver and kidney functions in experimental fluoride toxicity in rabbits. Twenty-four New Zealand White rabbits, 4 to 6 weeks old, weighing between 600 to 800 grams were divided into four equal groups of 6 animals each. Drinking water containing 50 (Gr.I), 100 (Gr.II), 200 (Gr.III) and 0 (Gr.IV, Control) μg/ mL added sodium fluoride were provided ad libitum for a period of 90 days. Blood samples were collected on day 0, 45 and 90 by cardiac puncture using heparinized sterile syringes and plasma were separated.  Significant increase in plasma cortisole level was observed in all the fluoride treated groups on day 90. Cortisole level had high positive correlation (P= 0.948) with plasma fluoride concentration on day 90. Increase in lipid peroxides level and decrease in superoxide dismutase and catalase activities were observed in Group II and III on day 90. However, changes in these oxidative stress parameters did not show any consistent relationship with dose of fluoride exposure.  Increase in alanine amino transferase, aspirate amino transferase, alkaline phosphatase, blood urea nitrogen and creatinine levels suggested hepatotoxic and nephrotoxic effects of excess fluoride intake in rabbits, which were more marked on day 90 in Group II and III animals.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/28159 must be provided.

1. Effect of area specific mineral mixture supplementation on clinico-haematological and mineral profile of buffaloes suffering from fluorosis
2. Alterations in blood concentrations of macro- and micro-minerals in water buffaloes living in fluorosis endemic areas of Punjab