1-Aryl-2-aminoimidazoline were used to synthesize many chain and fused imidazoline derivatives exhibiting pharmacological activity. Compounds bearing the 1-aryl substituted were found to process significant central activity, especially antinociceptive and serotonergic [1-3].
   When reserching new compounds with potential pharmacological activity 1-aryl-6-(4-chlorbenzy)-5,7(1H0-2,3-dihydroimidazo[1,2-a][1,3,5]trizines were received. This heterocyclic system was obtained in two-step reaction.
   Novel cyclic derivatives of dihydroimidazo[1,2-a][1,3,5]trizines were receicved by condensation of 1-(1-arylimidazolidyn-2-ylideno)-3-(4-chlrbenzyl)urea with CDI.
   The structure of all new compounds was confirmed by elementar analysis, as well by the 1H NMR.

[1] D. Matosiuk, S. Fidecka, L. Antkiewicz-Michaluk, I. Dybała, A.E.Kozioł, Eur. J. Med.. Chem. 2001, 36 783
[2] K.Sztanke, S. Fidecka, E. Kędzierska, Z. Karczmarzyk, K. Pihlaja, D. Matosiuk, Eur. J. Med.. Chem. 2005, 40 127
[3] D. Matosiuk, S. Fidecka, L. Antkiewicz-Michaluk, J. Lipkowski, I. Dybała, A.E.Kozioł, Eur. J. Med.. Chem. 2002, 37 761

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