Synthetic derivatives of pyrimidine are a significant group of medicines that is characterized by varied pharmacological activity, hypoglycaemics among others.

When searching new compounds with potential pharmacological activity 2-arylsulfonylimino-6-alkylperhydropirydo[4,3-d]pyrymidines derivatives were obtained. These compounds were synthesized by condensation of dimethyl N-arylsulfonyliminodithioic acid esters with respective 1-alkyl-3-amine-4-amine- methylpiperydines, isolation of intermadiate products (isothiourea derivatives ) and their thermal cyclization to 2-arylsulfonylimino-6-alkylperhydropirydo[4,3-d]pyrimidines.

Cyclic derivatives obtained in that way can exist in three tautomeric forms ( see scheme)

R = Cl R₁ = C₂H₅

R = CH₃ R₁ = C₂H₅

R = CH₃ R₁ = C₃H₇

The structure of new compounds was confirmed by elemental analysis, as well by the ¹H NMR, ¹³C NMR and MS spectra.

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