A variety of pharmaceutical preparations, which are applied in the management of non-infectious diseases, have shown in vitro some antimicrobial activity. These drugs are called “non-antibiotics”. So far, a lot of attention has been focused on phenothiazines, thioxanthenes and other agents with affinities to cellular transport systems or agents showing other inhibition mechanism. Several authors confirmed that some non-antibiotics are “helper compounds”, which enhance the in vitro activity of certain antibiotics against specific bacteria (ex. omeprazole and nizatidine enhance the effect of metronidazole on Helicobacter pylori). The aim of this study was to detect and characterise the antimicrobial activity of non-antibiotic drugs, selected from the pharmaceutical products analysed during the state control performed in National Medicines Institute. Over 90 pharmaceutical preparations were randomly chosen from different groups of drugs. The surveillance study was performed on standard ATCC microbial strains used for drug control: S. aureus, E. coli, P. aeruginosa and C. albicans. It was shown that the drugs listed below inhibited growth of at least one of the examined strains: Arketis 20 mg tab. (paroxetine), Buvasodil 150 mg tab. (buflomedile), Halidor 100 mg tab. (bencyclane), Hydroxyzinum espefa 25 mg tab. (hydroxyzine), Norifaz 35 mg tab. (risedronate), Strattera 60 mg cap. (atomoxetine), Tamiflu 75 mg tab. (oseltamivire), Valpro-ratiopharm Chrono 300 mg tab. (valproate), Vetminth oral paste (24+3) g/100 ml (niclozamide, oxybendazole). Atomoxetine and bencyclane showed broad activity spectrum. They inhibited growth of all examined strains (MIC of atomoxetine: 2.6 - 13 mg/ml; MIC of bencyclane: 12.5 - 31 mg/ml). The highest activity against Gram-negative bacteria was found for risendronate (MIC 1.4 mg/ml). S. aureus was susceptible to the mixture of niclozamide and oxybendazole in concentration 0.24 and 0.03 mg/ml, resp. Paroxetine was active against S. aureus and E. coli (MIC 2.5 mg/ml and 5 mg/ml, resp.). For twenty-fold diluted solution of Inhalol consisting of aromatherapy oils, antiseptic activity was found against: S. aureus, E. coli and C. albicans. The antimicrobial activity of the pharmaceutical products necessitates neutralisation of this activity during pharmacopoeial microbial purity assays.

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1. Microwave-assisted synthesis and antimicrobial activity of O-alkylamino derivatives of benzofurancarboxylic acids
2. Examination of antimicrobial activity of selected non-antibiotic products
3. Examination of antibacterial and antifungal activity of selected non-antibiotic products
4. EVALUATION OF ANTIMICROBIAL ACTIVITY OF SELECTED NON-ANTIBIOTIC DRUGS