A variety of pharmaceutical preparations, which are applied in the management of non-infectious diseases, have shown in vitro some antimicrobial activity. These drugs are called “non-antibiotics”. So far, a lot of attention has been focused on thioxanthenes, phenothiazines, and other agents with affinities to cellular transport systems or agents showing other inhibition mechanism. Several authors confirmed that some non-antibiotics are “helper compounds”, which enhance the in vitro activity of certain antibiotics against specific bacteria (ex. omeprazole and nizatidine enhance the effect of metronidazole on Helicobacter pylori). The aim of this study was to detect and characterise the antimicrobial activity of non-antibiotic drugs, obtained during a routine state control of pharmaceutical products from the Polish market performed by National Medicines Institute. Over 90 pharmaceutical preparations were randomly chosen from different groups of drugs. The surveillance study was performed on standard ATCC microbial strains used for drug control: S. aureus, E. coli, P. aeruginosa and C. albicans. It was shown that the drugs listed below inhibited growth of at least one of the examined strains: Nolvadox 20 mg tabl. (tamoxifen), Atorvox 20  mg tabl. (atorvastatine), Rilutec 50  mg tabl. (riluzole), Alpha Vibolex 600 mg caps. (alpha lipoic acid), Deprim forte 425 mg caps. (Hyperici herbae extr. siccum), Zokardis 30 mg tabl. (zofenopiril), Fevarin 50 mg tabl. (fluvoxamine), Pernazinum 100 mg tabl. (perazine), Rebetol 200 mg caps. (ribavirine). S. aureus was susceptible to over 70% of the drugs listed above. Fluvoxamine and perazine inhibited growth of S. aureus in concentration 2 mg/ml and E. coli in concentration 2 mg/ml and 4 mg/ml, respectively. C. albicans was susceptible to over 60% of the drugs listed above. C. albicans showed the strongest susceptibility to antiepileptic substance riluzole (MIC-3 mg/ml). Interestingly, natural product Deprim forte (dry extract from Hyperici herbae) in concentration 33 mg/ml inhibited growth of S. aureus. P. aeruginosa was susceptible to fluvoxamine and ribavirine (MIC-10 mg/ml). The antimicrobial activity of all drugs emphasises a necessity of neutralisation of their activity during microbial purity assays of pharmaceutical products.

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