Various compounds which are involved in the management of diseases of non-infectious aetiology have shown some antimicrobial activity in vitro, against bacteria and other microorganisms. Such compounds are called “non-antibiotics”. So far, a lot of attention has been focused on phenothiazines, thioxanthenes and other agents with affinities to cellular transport systems or agent showing other inhibition mechanism. Some authors confirmed that some non-antibiotics are helper compounds which enhance the in vitro activity of certain antibiotics against specific bacteria (e. nizatidine and omeprazole enhance the effect of metronidazole on Helicobacter pylori). The aim of this study was to detect and characterise the antimicrobial activity of non-antibiotic drugs, selected from the pharmaceutical products analysed during state control performed in National Medicines Institute in Poland. Over 90 pharmaceutical preparations were randomly chosen from different groups of drugs. The surveillance study was performed on standard ATCC microbial strains used for drug control: S. aureus, E. coli, P. aeruginosa and C. albicans. It was shown that the drugs listed below inhibited growth of at least one of the examined strains: Citabax 40 mg tabl. (citalopram), Clopidix 75 mg tabl. (clopigrel), Doculax 50 mg caps. (sodium docusate),  Glucobay 100 mg tabl. (acarbose), Nalgesin 550 mg tabl (naproxen), Simvacor 10 mg tabl. (simvastatine), Sylicaps 100 mg tabl. (sylimarine) and Vesicare 5 mg, 10 mg tabl. (solifenacin succinate). Staphylococcus aureus was susceptible to over 70% of the drugs listed above. The lowest inhibitory concentration was found for docusate sodium (3 mg/ml). Other chemical compounds showed activity against this microorganism in concentrations between 5 and 70 mg/ml. Acarbose and citalopram in concentration 7 mg/ml showed the strongest activity against E. coli. C. albicans showed the strongest susceptibility to simvastatine (MIC- 5 mg/ml). Interestingly, natural product – sylimarine extracted from Silybum marianum inhibited S. aureus in concentration 67 mg/ml. P. aeruginosa was resistant to all of the examined active substances. The antimicrobial activity of all drugs emphasises a necessity of the neutralisation of their activity during the microbial purity assays of pharmaceutical products.

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1. Examination of antimicrobial activity of selected non-antibiotic products
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3. Examination of antimicrobial activity of selected non-antibiotic products
4. EVALUATION OF ANTIMICROBIAL ACTIVITY OF SELECTED NON-ANTIBIOTIC DRUGS