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Kinetic study of hydroxyapatite formatioin from Ca(OH)2 and H3PO4

Dong Wook Kim 1In-Sun Cho 1Hae Lin Jang 1Hyun Suk Jung 2Kug Sun Hong 1

1. Seoul National University, Department of Materials Science and Engineering (MSE, SNU), San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-744, Korea, South
2. Kookmin University, School of Advanced Materials Engineering, Seoul 136-702, Korea, South


The process of hydroxyapatite (HAp) formation was investigated via an in-situ analysis by freeze drying the sampled products during the reaction. It is confirmed that HAp is formed from Ca(OH)2 and H3PO4 via dicalcium phosphate dihydrate (DCPD) phase as an only precursor, which has been monitored by XRD, FT-IR, 1H and 31P MAS NMR and pH measurements. Additionally, we demonstrated the kinetics of HAp formation with an experimental proof that is the FESEM images of powders at various time intervals. It was directly observed how the change of plane and cross-section in powders were developed. The process of HAp formation was made up of the formation of DCPD and the transformation of DCPD to HAp. This transformation was developed by initially (1) heterogeneous nucleation-controlled and then (2) gradual transformation in volume of DCPD. However, the transformation was retarded by the slow diffusion process and the slow dissolution of residual Ca(OH)2. Further works are needed to enhance the crystallization process with a fairly simple process.


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Related papers

Presentation: Poster at E-MRS Fall Meeting 2008, Symposium L, by Dong Wook Kim
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-05-06 18:00
Revised:   2009-06-07 00:48