A substrate used in the study was 5-hydroxymethyl-6-methyl-2-phe-
nyl-4- phenylaminepirymidine (1), which with SOCl₂ was transformed into 5-chloromethyl derivative of pirimidine 2. The derivative 2 was treated with various aromatic amines, obtaining amino-derivatives 3, which in turn were entered into Mannich reaction, producing derivatives of 1,2,3,4-tetraliydropirimid [4,5- d] pirimidine 4 and 5. Those newly obtained compounds were microbiologically tested in selected strains of: Bacillus subtilis, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus epidermidis, Stapylococcus aureus, Klebsiella pneumoniae. Anti-fungal tests were also realised on Candida albicans. Interesting microbiological results were achieved, both antibacterial and antifungal.

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1. SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 1, 5, 5-TRIMETHYL-3-CYCLOHEPTENE DERIVATIVES
2. SYNTHESIS AND BIOLOGICAL ACTIVITY OF PYRIMIDINE 5-TERPENO DERIVATIVES