Application of the allyloxycarbonyl protecting group has no precedence in taxane chemistry. We have demonstrated that it's use simplifies the synthetic pathways leading to the title drug substances and can be treated as the technical process innovation.

Novel route for the synthesis of docetaxel and paclitaxel consists of: esterification of 7,10-O-diallyloxycarbonyl-10-desacetylbaccatin III or 7-O-allyloxycarbonylbaccatin III by (4S,5R)-N-allyloxycarbonyl-2-metho­xyphenyl-4-phenyl-1,3-oxazo­lidine-
5-carboxylic acid, subsequent one step removal of all allyloxycarbonyl protecting groups in the esterification products, the cleavage of oxazolidine ring, and finally the conversion of 13-[(2R,3S)-3- phe­nylisoserinyl]-10-desacetyllbaccatin III to docetaxel in the presence of di-tert-butyl dicarbo­nate or 13-[(2R,3S)-3-phenyliso-seri-
nyl]-baccatin III to paclitaxel in the presence of benzoyl chloride.

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