prof Wiesław Szeja

Affiliation:

Silesian University of Technology, Department of Organic Chem., Bioorganic Chem. and Biotechnol.

Participant:

V Multidyscyplinarna Konferencja Nauki o Leku

Participant:

VII Multidyscyplinarna Konferencja Nauki o Leku

Participant:

VIII Multidyscyplinarna Konferencja Nauki o Leku

Participant:

IX Multidyscyplinarna Konferencja Nauki o Leku

Publications:

1. 1-THIOSUGARS: SYNTHESIS AND BIOLOGICAL ACTIVITY AGAINST CSFV GLYCOPROTEINS.
2. (5-Nitro-2-pyridyl) 1-thioglycosides: application in synthesis of analogues of glycosyltransferases natural substrates
3. Antiproliferative activity of novel synthetic genistein glycoside derivatives
4. Application of 2-Nitroglycals in the Synthesis of Biologically Active Glycoconjugates
5. Comparison of biological activity and stability of selected C-glycosidic and O-glycosidic genistein derivatives
6. Enzymatic synthesis of beta-2-deoxy-D-galactopyrano- sides from glycals
7. Evaluation of cytoxicity of glycosyl uridine derivatives
8. Fucosyl derivatives in the synthesis of uridine glycoconjugates - potential glycosyltransferase inhibitors
9. Fucosyl thiocarbamates, synthesis and application in glycosylation
10. Fungicidal activity of thionocarbamates derivatives of alcohols
11. Glycoconjugates, products of uridine derivatives phosphitylation and oxidation as glycosyltransferases potential inhibitors
12. Glycosyl O- and S- N-allyl thiocarbamates in the synthesis oligosaccharides.
13. Glycosyl thiocarbamates in orthogonal synthesis of oligosaccharides
14. Hexenoses in design of glycoconjugates – from chemistry to function
15. Isolation and application of β-galactosidases  in the synthesis of 2-deoxy-β-D-galactosides 
16. Isolation of galactosyltransferases from swine tissues. Screening of enzymatic activities
17. N-Phenyl thionocarbamates derivatives of alcohols as donors protecting groups in carbohydrate chemistry
18. Prediction of intestinal absorption and metabolism of biologically active genistein derivatives
19. Regioselective protection of functional groups in the na- tural compounds.
20. Sugars in new drug design. Sugar moiety structure as a principal determinant of antitumor glycoconjugates biological activity.
21. Synthesis and biological activity of synthetic β-D-glucose and β-D-galactose conjugates with various acyclic nucleosides
22. Synthesis and in vitro screening of antiproliferative activity of C-glycosides, the derivatives of genistein and daidzein in selected cancer cell lines
23. Synthesis of 1’-(saccharide)substituted 28-O-(1’H-[1’,2’,3’]triazolyl-4’-methyl) derivatives of protoescigenin
24. Synthesis of galactothiophosphoesters of uridine and preliminary tests to evaluate their activity against selected glycosyltransferases
25. Synthesis of glycosyltransferases natural substrate analogues from 1,6-anhydrosugars and acyclic uridine derivatives
26. SYNTHESIS OF URIDINE DERIVATIVES OF 2-DEOXY SUGARS AND THEIR BIOLOGICAL ACTIVITY
27. The role of a sugar moiety in new genitein derivatives affecting proliferation and apoptosis of cancer cells
28. Tiocarbamates derivatives of p-nitrobenzyl alcohol as donors in the synthesis of glycoconjugates
29. Unsaturated saccharides as a useful chiral synthons and their application in synthesis  of polyphenol glycoconjugates - potential antiproliferative agents
30. Uridine derivatives of heteroaryl 1-thioglycosides: synthesis and biological activity against CSFV glycoproteins