The reason for the extended use of titanium and its alloys as implant biomaterials stems from their lower elastic modulus, their superior biocompatibility and improved corrosion resistance compared to the more conventional stainless steel and cobalt-based alloys. Nanostructured titanium-based biomaterials with tailored porosity are important for cell-adhesion, viability, differentiation and growth. Powder metallurgy technologies like foaming or low-density core processing were recently used for the surface modification of titanium alloy implant bodies to stimulate bone in-growth and improve osseointegration and cell-adhesion, which in turn play a key role in the acceptance of the implants. We here report on preliminary results concerning the synthesis of mesoporous titanium alloy bodies by spark plasma sintering. Nanocrystalline cpTi, Ti-6Al-4V, Ti-Al-V-Cr and Ti-Mn-V-Cr-Al alloy powders were prepared by high-energy wet-milling and sintered to either non-porous (cp Ti, Ti-Al-V) or uniform porous (Ti-Al-V-Cr and Ti-Mn-V-Cr-Al) bulk specimens by spark plasma sintering in vacuum. Cellular interactions with the porous titanium alloy surfaces were tested with the osteoblast-like osteosarcoma cell line MG-63. Cell morphology was investigated using scanning electron microscopy (SEM). The results of the SEM analysis were further correlated with the alloy chemistry and the topographic features of the surface, namely porosity and roughness.

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