Sclerosis and its consequences as the appearing circulatory failures, mainly manifested as disorder of the coronary, celebral and peripheral circulation are at present dominant wholesome problems of modern society. Among the numerous factors causing sclerosis an important reason are disturbances of lipides and lipoproteins. They are characterized by increasing content of cholesterol and/or triglicerides in plasma.

Medicines - derivatives of lovastatin are inhibitors of reductase of hydroxylmethylglutaryl - coenzyme A, an enzyme which catalysed the early stage of synthesis of cholesterol.

Conditions were elaborated for the identification of hiperlipidemia compound - simvastatin, lovastatin, calcium salt of atorvastatin, sodium salt of fluvastatin and sodium salt of pravastatin and three preparations (tablets or capsules), containing the above mentioned compounds - Lipitor - tablets, Lescol - capsules and Pravastatin - tablets.

The elaborated conditions were shown as a good ones for quantitative determination of compounds of this group by gas chromatographic method present in substances and pharmaceuticals. Six compounds were selected for GC assays. The method of internal standard was applied.

For identification of a mixture of the derivatives of lovastatin (statins) the capillary column CP-Sil 5 CB (HP-1), flame - ionization detector and two differences programmes were used.

For determination of substances from this group the capillary column CP-Sil 5, FID detector and temperatures were used: column temperature - 260 °C ( 295 °C only for calcium salt of

atorvastatin); detector temperature - 320 °C and injector temperature - 300 °C.

The statistical data, indicate satisfactory precision and accuracy of the GC method, both for the compounds and pharmaceuticals.

To compare the obtained results, another set of experiments was performed using a HPLC method, which is routinely applied to studying compounds from the group of statins in the same substances and pharmaceutical preparations.

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