Pramipexole is a novel nonergot dopamine agonist which has high selectivity for interacting with dopamine D₂ receptors. It is effective in early Parkinson,s disease as monotherapy and as adjunctive therapy with L-dopa in advanced stages of the disease.

Known, two-steps method for preparation of pramipexole (3) is based on acylation reaction of diamine 1 with propionic anhydride. The obtained amide 2 is subsequently reduced using borane to give final product 3 with 65% yield.

Now, we present novel, more economic and safe procedure for obtaining pramipexole. Our one-step method requires only alkylation of 1 using n-propyl tosylate. Dangerous reduction with borane is eliminated and the final compound is obtained with similar yield as in a previous method.

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