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Model of Regeneration Processes Prognosis at Application of Natural Bioimplants

Lyudmila I. Donchenko 

Donetsk State Medicine University, Scientific Research Institute for Traumatology & Orthopeadics (DonIT&Or), 106, Artema St, Donetsk 83048, Ukraine

Abstract

Bioimplantation is an actual direction of advanced medicine. Development of various kind of implantable biomaterials with the given strength characteristics, preservation of vital biomechanical properties, with the low immunogenity and high level inductivity of regenerative processes causes the appropriateness of studies of biochemical reactions after implantation of biomaterials. This will allow one to elucidate the peculiarities of regeneration processes at application of different kinds of bioimplantable materials.
In this work we have studied the electrolyte exchange and enzyme activity after transplantation with the application of natural materials. The content of macro-elements and enzyme activity at auto- and allo-transplantation of Achilles' tendon were investigated for thirty rabbits of Chinchilla breed in the comparative aspect.
We have investigated blood sera for both groups of animals after transplantations of tendons after 7, 14, 21, 45 and 90 days.
It was revealed that the contents in the blood serum of sodium, amylase acid phosphatase activity which were determined at earlier terms after transplantation are the informative data of prognosis of regeneration processes evolution. The obtained results were the basis for development of algorithm of regeneration processes prognosis Approbation of developed algorithm at clinic conditions was revealed the high accuracy (84%) of true prognosis.

 

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Related papers

Presentation: poster at E-MRS Fall Meeting 2003, Symposium E, by Lyudmila I. Donchenko
See On-line Journal of E-MRS Fall Meeting 2003

Submitted: 2003-05-07 16:51
Revised:   2009-06-08 12:55