Soy (Glycine max (L.) Merr.) is an annual plant cultivated worldwide mostly for high-quality food. Moreover, due to its pharmacological properties it is widely used in pharmacy for alleviating the symptoms of osteoporosis. Numerous literature data suggest that isoflavones, the major phenolic compounds present in soy, protect against post-menopausal osteoporosis associated with endogenous estrogen deficiency [1]. On the other hand, strontium salts have shown unique pharmacological effects on bone resorption and formation [2, 3].

The aim of our paper was investigation the influence of strontium ions fertilization on isoflavones content in Glycine max. Our research can be useful to obtain herbal preparations containing both phytoestrogens and strontium to prevent postmenopausal osteoporosis.

The analysis of isoflavones was performed by HPLC-DAD method; the content of strontium in plant depending on its concentration in growth media was determined by flame atomic absorption spectrometry (High-Resolution Continuum Source atomic absorption spectrometer ContrAA 700).

 References:

[1] Wildman, R. E. C. Handbook of nutraceuticals and functional foods. In: Hendrich, S.; Murphy, P. A. Isoflavones. CRC Press, Boca Raton, 2006, pp 23–54.

[2] Marie, P. J.; Felsenberg, D.; Brandi, M. L. How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis. Osteoporosis Int. 2011, 22, 1659–1667.

[3] Stepan, J. J. Strontium ranelate: in search for the mechanism of action. J Bone Miner Metab. 2013, 31, 606–612.

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1. Quantitative analysis of  triterpenic acids in Viscum album from various hosts
2. The phenolic acids content and antioxidant activity of Cimicifuga racemosa
3. The application of HPLC method for investigating the stability of Vitamin C