Cimicifuga racemosa (L.) Nutt. (black cohosh) is a perennial herb with a diverse and long history of medicinal use. The roots and rhizomes are traditionally employed to treat a variety of disorders, e.g. malaria, rheumatism, sore throat, menstrual irregularities and for the relief of menopause-related symptoms [1,2]. The two groups of secondary metabolites: triterpene glycosides and phenolics compounds are the main bioactive constituents of black cohosh  [3]

In the present investigation, the content of phenolic acids in two varieties: C. racemosa (L.) Nutt. var. racemosa and C. racemosa (L.) Nutt. var. cordifolia (Pursh) Gray was determined by HPLC method in reversed-phase system. Analysis was performed on C18 column using mixture of acetonitrile, water and trifluoroacetic acid as a mobile phase

Moreover, the antioxidant activity of metanolic extracts from roots and rhizomes of C. racemosa was investigated. DPPH test with ascorbic acid as a references compound was used for the assay.

References:

[1] B. Jiang, H. Yang, P. Nuntanakorn, M.J. Balick, F. Kronenberg, E.J. Kennelly:  J. Ethnopharmacol. 96, 521–528, 2005.

[2] R. Margaret: Clin. Obstet. Gynecol. 23, 151–161, 2009.

[3] Z. Hui, M. Xiaoyan, Y. Mukuna, W. Ke, Y. Liyuan, Z. Sainan, J. Jing, Q. Lihua, B. Wenpei: J. Ethnopharmacol. 142, 769–775. 2012

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