Have been developed and manufactured biomaterials belonging to  family based formulations Portland cement, as in the case of ProRoot MTA or MTA Angelus, while easy to be activated powders with suitable  fluids to produce homogenous pastes.

It were developed  and manufactured materials with contrast radiology, optimal consistency and good workability, adequate mechanical strength for use in endodontic treatment.

Also preferably be assessed fact that aqueous extracts of these biomaterials exhibit a pH of 10.2 and rising to 11.52 after 24 h. Developed and manufactured materials release significant quantities of calcium ions which should result in a biological environment stimulation of reparative processes pulp and repair processes in the bone tissue surrounding the root of the tooth. Based on this results may be assumed that developed materials should provide good root end  filling and pulp capping.

Cytotoxicity developed cements for use in endodontics was performed by indirect contact with the monolayer cell culture L929 fibroblasts. It was no toxic effect of developed materials.
Also biomaterials showed no genotoxic potential against strains of Salmonella typhimurium TA 98 and Salmonella typhimurium TA 100 with or without metabolic activation in rat liver microsomal fraction S9 in the Ames test.

The developed biomaterials have antibacterial activity against the strains of Streptococcus mutans, Streptococcus sanguinis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa.
Based on the results of the in vivo evaluation stated that the obtained  biomaterials were characterized  high biocompatibility tested with the muscle tissue of rats and bone tissue of rabbits.Moreover they initiated in the soft tissue cementogenesis process.
Developed biocompatible biomaterials can be used in dentistry for endodontic  treatment.

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