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Antibiotics adsorption and desorption processes from the silica particles surface

Paweł Biernat 1Beata Borak 2Janusz Pluta 1

1. Wrocław Medical University, Chair and Department of Pharmaceutical Technology (AM), Szewska 38, Wrocław 50-139, Poland
2. Wroclaw University of Technology, Institute of Materials Science and Applied Mechanics (PWr - IMMT), Smoluchowskiego 25, Wrocław 50-370, Poland


Recently nanotechnology has been rapidly coming out in biomedical applications, such as drug or gene delivery carriers, cancer therapy and diagnosis of diseases. A significant advances in drug-delivery systems have enabled more effective drug administration. A range of organic systems, such as: micelles, liposomes, dendrimers and polymeric nanoparticles have been designed to deliver drugs to specific organs. All mentioned organic systems suffer from limitations, including poor thermal and chemical stability and rapid elimination by the immune system [1]. Inorganic materials, especially silica has a fundamental advantages over the organic materials. Amorphous SiO2, in contrast to crystalline silica, offers a biocompatible, stable and promising alternative. The advantages of silica lie also in well-developed silane chemistry and easy preparation. Bioactive molecules (drugs) can be adsorbed on the silica surface and encapsulated within silica materials by the sol-gel method or emulsion chemistry. Sol-gel method enable the production of various materials with homogeneous drug distribution and permit ambient temperature processing, necessary for handling active molecules and biological. The silica materials employed as a matrix are chemically inert towards the encapsulated substances [2].

In this work we are presented the study of the adsorption and desorption of some antibiotics (ceftazidime, chloramphenicol and gentamicin) on/from silica particles surface. Silica particles have diameter size about 150 nm and were obtained by the sol-gel method. Loading of the particles was performed by immersion method, in which the particles were diped into a drug solution with definite concentration. After the centrifugation the supernatant was analyzed using a spectrophotometer. Langmuir and Freundlich isotherms were applied to the experimental data obtained for researched antibiotics.






[1] C. Barbé, J. Bartlett, l. Kong, K. Finnie, H.Q. Lin, M. Larkin, S. Calleja, A. Bush, G. Calleja “Silica Particles: A Novel Drug-Delivery System” Advanced Materials 16 (2004) 1959-1966

[2] M.M. van Schooneveld at all. “Improved Biocompatibility and Pharmacokinetics of Silica Nanoparticles by Means of a Lipid Coating: A Multimodality Investigation” Nano Lett. 8 (2008) 2517-2525

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Presentation: Poster at Nano-Biotechnologia PL, by Beata Borak
See On-line Journal of Nano-Biotechnologia PL

Submitted: 2012-06-26 16:24
Revised:   2012-06-26 16:24