Fluoride Toxicity due to the presence of higher levels of fluoride in drinking water (>1.5ppm) may be serious problems in health of the children and people in general. In the state of Rajasthan, almost all districts have high Fluoride (up to 18.0 ppm) in their drinking / ground water sources and about 11 million of the populations are at risk. The aim of the present study was to investigate the status of vitamins (A, E, C and D), minerals (Cu, Zn, Fe and Se) in fluoride exposed children (age 10 to 15 years). In the present study, 32 children were selected from the high fluoride region of the eastern regions of the Jaipur, where fluoride content in water is 5.5 ± 1.2 ppm. Moreover, age matched controls were selected from the Jaipur district where fluoride content in water was less than 1.5 ppm.  3.0 ml of blood sample were taken for estimation of vitamins and oxidative stress parameters namely, lipid peroxide level (LPO), superoxide dismutase, catalase and reduced glutathione content. Moreover, evaluation of  Fe, Cu, Zn and Se in the plasma using atomic absorption spectrophotometer. It was observed significantly reduction in vitamin E, C and D when compared with the age matched controls. On the other hand lipid peroxide levels and Fe were increased. The depleted antioxidant enzymes ie., SOD, catalase, GSH and metals Cu, Zn and Se levels in subjects as compared with the controls. On the basis of the results it may conclude that fluoride exposure promote oxidative stress and alteration in vitamins and minerals. These alterations may induce pathophysiological activities due to lack of vitamin and minerals. However, further in depth studies is required for the understanding of pathophysiology of fluorosis.

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