The fabrication and characterisation of potentially implantable bioelectronic devices,¹ e.g., biosensors and biofuel cells, is important for different biomedical applications. Since the topic delineated in the title is very broad the lecture will mostly be focused on glucose sensitive amperometric biosensors and glucose/oxygen biofuel cells operating in human physiological fluids. Nowadays these devices have been designed for and tested in both in vitro and in vivo situations,^2-5 and also practically exploited.^6-7

Firstly, major classifications of biodevices will be described and basic mechanisms of their function including useful mathematical apparatus will be given. Secondly, historical aspects on their fabrication, investigation, and application will be presented.^8-10 This would include recently designed biodevices based on nanotechnological achievements, which were characterised in detail with the help of surface electrochemistry, ellipsometry, AFM, and SEM. During the lecture significant attention will be also devoted to proper surfacemodification procedures to produce bionanostrucutres serving as sensitive, linear, and stable biosensors, as well as bioanodes and biocathodes of efficient and stable biofuel cells. Finally, further perspectives in the field of potentially implantable bioelectronics will be discussed.

1. E. Katz. Electroanalysis, 2006, 18, 1855
2. D. Gough et al. Science Translational Medicine, 2010, 2, 42
3. V. Coman et al. Fuel Cells, 2010, 10, 9
4. P. Cinquin et al. PLoS One, 2010, 5, 5
5. A. Zebda et al. Nature Communications, 2011, DOI: 10.1038/ncomms1365
6. E. Dassau et al. Diabetes Care, 2010, 33, 1249
7. E. Cengiz et al. Expert Review of Medical Devices, 2011, 8, 449
8. M. Beltzer and J. Batzold. Proc. Intersoc. Energy Convers. Eng. Conf., 4^th, 1969, 354
9. S. Barton at al. Chemical Reviews, 2004, 104, 4867
10. A. Heller. Physical Chemistry Chemical Physics, 2004, 6, 209.

The work has been supported financially by the European Commission (FP7 project NMP4-SL-2009-229255) and the Swedish Research Council (project 2009-3266).

1. PRESENTATION: Potentially implantable bioelectronic devices for biosensing and biofuel cell applications, Microsoft Office Document, 0MB

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