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Effect of the increment of a polymeric chain coating over Fe3O4 particles used for magnetic separation
|Raul Terrazas Reza 1, Carlos A. Martínez 1, Dario Bueno Baques 2, Perla E. Garcia-Casillas 1|
1. Universidad Autonoma de Ciudad Juarez, Ave. del Charro 450 Norte, Juarez 32360, Mexico
The development of magnetic separation techniques using small magnetic particles has been of great attention for biomedical applications. Such applications involve strict requirements on particles characteristics such as: chemical composition, size and size distribution, crystalline structure, stability of magnetic properties, surface morphology, adsorption properties and low toxicity, among others. The effect that an increased polymeric chain has over this type of application has been studied, however, in only few investigations. Based on this fact, spherical magnetite nanoparticles with size of 200 nm were synthesized by chemical coprecipitation under refluxing and aging conditions, being then coated and functionalized with different types of polymer chains onto particle surface. In this research, silica was the minor polymeric chain used, while aminosilane was the other polymeric material involved. In order to increase the chain length, silica coating was applied followed by a second aminosilane shell. Protein adsorption on magnetite nanoparticles coated with polymeric chains was studied. The protein adhesion for magnetite-silica, magnetite-aminosilane and magnetite-silica-aminosilane arrays was 12.5%, 79.5% and 145.75% higher than pure magnetite, respectively. The result shows a dependence of the protein adsorption with the increased chain. The magnetic properties were slightly modified, having that the saturation magnetization decreased with the application of the coating; however all coated magnetite nanoparticles showed a superparamagnetic behavior translated into a fast response to an external magnetic field applied.
X-Ray Diffraction (XRD) was used to confirm the magnetite (Fe3O4) phase. The particle size distribution and morphology of nanoparticles with and without coateing were characterized by Field Emission Scanning Electron Microscope (FE-SEM).
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Presentation: Poster at E-MRS Fall Meeting 2009, Symposium F, by Perla E. Garcia-Casillas
See On-line Journal of E-MRS Fall Meeting 2009
Submitted: 2009-05-26 04:38 Revised: 2009-06-30 20:02