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Polyester particles obtained by dialysis - new material for cell cultures

Mariusz Gadzinowski ,  Stanislaw Sosnowski ,  Stanislaw Słomkowski 

Polish Academy of Sciences, Center of Molecular and Macromolecular Studies (CMMS-PAS), Sienkiewicza 112, Łódź 90-363, Poland


We developed a new method for obtaining biodegradable poly(L,L-lactide) and poly(L,L-lactide-co-glycolide) particles by dialysis, which consists in the change of a polymer solvent to water. During this process the particles are formed by polymer precipitation. We used poly(ethylene glycol)-b-polyglycidol-b-poly(L,L-lactide) block terpolymer as a stabilizer of the suspended matter.
Several polymer solvents such as THF, acetonitrile, 1,4-dioxane, DMSO and DMF were used. For poly(L,L-lactide-co-glycolide) used solvent does not affect neither shape nor size. In case of poly(L,L-lactide) we observed strong influence of the solvent on the particle shape and size.
The variations of process parameters lead to obtain a microporous particles, which can be applied as a biodegradable support for cell cultures.
By pressing and heating of polymer particles we have obtained a porous polymer samples, which can be used as a biodegradable support for cell culture. The influence of temperature, pressing condition on samples morphology are in progress.


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Related papers

Presentation: poster at E-MRS Fall Meeting 2004, Symposium B, by Mariusz Gadzinowski
See On-line Journal of E-MRS Fall Meeting 2004

Submitted: 2004-04-26 10:35
Revised:   2009-06-08 12:55