3D Laser Synthesis of Porous Tissue Scaffolds as repository for stem cells

Igor V. Shishkovsky 1Yuri G. Morozov 2Larisa T. Volova 3

1. P.N. Lebedev Physics Institute of RAS, Samara branch, Novo-Sadovaja st. 221, Samara 443011, Russian Federation
2. Institute of Structural Macrokinetics and Materials Science, Russian Academy of Sciences, Chernogolovka 142432, Russian Federation
3. Samara State Medical University, Samara 443096, Russian Federation

Abstract

General approach to the synthesis of porous functional meso-devices – bio compatible tissue-cellular scaffolds the based nitinol (NiTi phase with Shape Memory Effect property) or titanium by the SLS method and directed management (a priory, i.e. on stage of CAD) their physical-mechanical and physical-chemical characteristics is described.

Layer by layer It was synthesized as porous volume parts, which could be recommended for tissue-cellular scaffolds (matrixes), as solid 3D parts - from those biocompatible implant materials. Comparative histological and morphological analysis of medical applications for porous nitinol and titanium 3D parts is presented with connect to SEM-EDX structure and chemical element verification.

It was shown, that sintered porous titanium and nitinol is comfortable environment for stem cells. It allow to propose such tissue-cellular scaffolds as repository (matrix) for stem cell keeping and may be as basis for growth (recovery) demanded organs. It was remarked, that fabrication of nano substructure during SLS with self-organization by fractal type could be promoting the biomechanical integration of implant to a living tissue.

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Presentation: Oral at E-MRS Fall Meeting 2008, Symposium L, by Igor V. Shishkovsky
See On-line Journal of E-MRS Fall Meeting 2008

Submitted: 2008-05-12 10:51
Revised:   2009-06-07 00:48
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