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Nanostructure Processing of Advanced Biomaterials

Jackie Y. Ying 

Institute of Bioengineering and Nanotechnology (IBN), 31 Biopolis Way, The Nanos 04-01, Singapore 138669, Singapore


Nanostructured materials are of interest for a variety of applications. Through controlled synthesis in reverse microemulsions, my laboratory has achieved polymeric nanoparticles for the glucose-sensitive delivery of insulin. These stimuli-responsive materials allow for the appropriate insulin delivery to diabetic patients only when their blood sugar levels are high, without the need for external blood sugar monitoring. We have also developed apatite-polymer nanocomposite particles for the sustained, zero-order delivery of protein therapeutics. By adsorbing valuable bone morphogenetic proteins on carbonated apatite nanocrystals that are then encapsulated within biodegradable polymeric microparticles, we are able to achieve controlled release of this growth factor for the bone healing process over an extended period of time. Functionalized nanoparticles and quantum dots have also been tailored for bioimaging, biolabeling and bioseparation applications.

In addition, nanostructure processing has been employed in artificial implant and tissue engineering applications. For example, nanocomposite processing has been applied to obtain orthopedic implants and bone scaffolds with superior mechanical strength and bioactivity. By combining microfabrication and nanotechnology, we have also created various microstructures in kidney-specific dimensions and shapes. These structures can be used as bioartificial renal assist microdevices, and may serve as three-dimensional templates for tissue engineering.


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Presentation: Invited at E-MRS Fall Meeting 2007, Acta Materialia Gold Medal Workshop, by Jackie Y. Ying
See On-line Journal of E-MRS Fall Meeting 2007

Submitted: 2007-06-05 04:29
Revised:   2009-06-07 00:44