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Investigation of the effect of surface properties and stoichiometry on haemocompatibility of titanium nitride thin films

Varvara Karagkiozaki 1,2,  Stergios Logothetidis 1,  Sylvi Lousinian 1,  George Giannoglou 2,  Nikolaos P. Kalfagiannis 1

1. Aristotle University, Department of Physics., Thessaloniki 54124, Greece
2. Aristotle University, Department of Cardiology, Ahepa Hospital., Thessaloniki 54124, Greece

Abstract
Introduction: Growth interest in the study of Titanium nitride thin films as coatings for biomedical applications has been generated due to their good mechanical stability, chemical inertness and enhanced biocompatibility. The objectives of this study is to evaluate the thrombogenic potential and subsequent haemocompatibility of stoichiometric (TiN) and non- stoichiometric (TiNx) films and its correlation with chemical composition, surface, optical and electronic properties. The thin films were developed by magnetron sputtering under different deposition conditions, and human platelets response towards them was estimated by Atomic Force Microscope (AFM) observations. The surface topographic characteristics and reflection images of TiN nanocoatings were obtained with high resolution, by the implementation of Scanning Near Field Optical Microscope. In addition, Spectroscopic Ellipsometry in the energy region of 1.5-6.5 eV was used for compositional and stoichiometry characterization of TiNx films.

Results: It was found that the nitrogen partial pressure and the applied bias voltage during deposition influence the surface properties and stoichiometry of TiNx films whereas haemocompatibility was found to be related to these parameters. The platelets AFM study during one and two hours’ adhesion on TiNx films, revealed the variation in their morphological characteristics indicative of different degrees of platelet activation.Thrombogenicity of the examined films was correlated with surface nanotopography and their stoichiometry. Therefore, it can be deduced that the stoichiometry and surface characteristics of TiNx films influence their haemocompatibility paving the way for the improvement of their biological properties.

 

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Presentation: Poster at E-MRS Fall Meeting 2007, Symposium J, by Stergios Logothetidis
See On-line Journal of E-MRS Fall Meeting 2007

Submitted: 2007-05-12 21:43
Revised:   2009-06-07 00:44