Glycophorin is the main integral glycoprotein of human erythrocyte membranes. Sialic acid residues in oligosaccharide chains of glycophorin establishes negative charges on the surface of red blood cells, which create electrostatic intermolecular repelling forces.

THE AIM: The aim of this work was to determine the monosaccharides profile of glycophorin isolated from erythrocytes of persons being immediately after a long lasting drinking period, and after 30 days of treatment

MATERIAL AND METHOD: 12 persons were taken into the hospital after long-term alcohol drinking period. The glycophorin from erythrocytes of their blood was isolated before, and after 30 days of treatment. In glycophorin, the contents of: N-acetylgalactosamine (GalNAc), N-acetyloglucosamine (GlcNAc), fucose (Fuc), mannose (Man) and galactose (Gal), were determined by gas chromatography.

The statistical analysis was carried out with the Mann-Whithey’s test. As the level of statistic relevance p<0.05 was accepted.

RESULTS: We show that in glycophorin of persons after a long lasting drinking period treated for 30 days, have significantly increased contents of Fuc (p=0.047) and Man (p=0.052) and tendency to increase in amount of Gal (p=0.078). GlcNAc contents was significantly decreased (p=0.029) and GalNAc content (p=0.12) remained almost unreduced.

CONCLUSION: In conclusion it can be stated, that long lasting alcohol intoxication significantly changes composition of glycophorin oligosaccharide chains.

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