The aminocarbonyl derivatives of 1-aryl-2-imidazolidine-2 both chain or fused were found to have significant antinociceptive activity connected with activation of the MOP (mu opioid protein) receptor [1-3]. Recent results on the chain (imidazol-2-yl)urea derivatives are implementing the pharmacophorie model with new features, which have to be taken under consideration in planning further synthesis.

Series A compounds exhibited significant antinociceptive activity in the "writhing test", reversed by small dose (5mg kg^-1 i.p.) of naloxon.

R = H, 2-CH₃, 4-CH₃, 2-OCH₃, 4-OCH₃, 2-Cl, 3-Cl, 4-Cl

n = 1, 2

The structure of all new compounds was confirmed by elemental analysis, as well by the ¹H NMR spectra.

[1] D. Matosiuk, S. Fidecka, L. Antkiewicz-Michaluk, I. Dybała, A.E.Kozioł, Eur. J. Med.. Chem. 2001, 36, 783.

[2] D. Matosiuk, S. Fidecka, L. Antkiewicz-Michaluk, J. Lipkowski, I. Dybała, A.E.Kozioł, Eur. J. Med.. Chem. 2002, 37, 761.

[3] K.Sztanke, S. Fidecka, E. Kędzierska, Z. Karczmarzyk, K. Pihlaja, D. Matosiuk, Eur. J. Med.. Chem. 2005, 40, 127.

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