The aminocarbonyl derivatives of 1- aryl-2-imidazolidine-2 have significant antinociceptive activity connected with activation of the MOP (mu opioid protein) receptor [1-3].The syntnetic derivatives of triazepine form are various and important group of medicine.In the search for new derivatives with potential pharmacological activity received of new imidazo [1,2-a][1,3,5]triazine. New 1-(2-pirydynyl)-6-fenyl(benzyl)-5,6,8(1H)-dioxoimidazo[1,2-a][1,3,5]triazine and 1-[2-(5-nitro)pirydynyl]-6-fenyl(benzyl)-5,6,8(1H)- dioxoimidazo[1,2-a][1,3,5]triazine were synthesised in reaction of adequate substituted 1-[(2-pirydynyl)imidazolidine-2-ylideno]- 3-fenyl(benzyl)urea with CDI.

The structure of all new compounds was confirmed by elementar analysis, as well by the ¹H NMR.

[1] D. Matosiuk, S. Fidecka, L. Antkiewicz-Michaluk, I. Dybała, A.E.Kozioł, Eur. J. Med.. Chem. 2001, 36 783

[2] D. Matosiuk, S. Fidecka, L. Antkiewicz-Michaluk, J. Lipkowski, I. Dybała, A.E.Kozioł, Eur. J. Med.. Chem. 2002, 37 761

[3] K.Sztanke, S. Fidecka, E. Kędzierska, Z. Karczmarzyk, K. Pihlaja, D. Matosiuk, Eur. J. Med.. Chem. 2005, 40 127

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/22954 must be provided.

1. Comparison of combined effects of 5-fluorouracil and allysin after concurrent treatment in colon and breast cancer cell lines
2. Synthesis of new 1-(1-arylimidazolin-2-ylo)-3-(4-methoxyphenyl)urea derivatives.
3. Sulforaphane modulates MRP expression and activity in Caco-2 cells
4. New 1-aryl-6-benzyl imidazo[1,2-a][1,3,5]triazines with potential pharmacological activity.
5. The combined effect of 5-fluorouracil and sulforaphane in prostate cancer cell line
6. Functional activity of new derivatives of dextromethorphan as allosteric inhibitors of α3β4 nicotinic acetylocholine receptor.
7. New imidazo[1,2-a][1,3,5]triazine with potential pharmacological activity
8. NEW AMINOCARBONYL DERIVATIVES OF 1-ARYLIMIDAZOLIDINE-2 WITH POTENTIAL PHARMACOLOGICAL ACTIVITY.
9. THEORETICAL STUDIES ON THE STERICAL PREREQUISITES FOR ACTIVE DOMAIN OF THE SEROTONERGIC 5-HT_1A RECEPTOR.
10. INVESTIGATION OF THE RELATIONSHIP BETWEEN LIPOPHILICITY AND THE STRUCTURE OF PERHYDROPYRIMIDINE DERIVATIVES BY THIN-LAYER REVERSED-PHASE CHROMATOGRAPHY.
11. PREPARATION OF NEW DERIVATIVES OF 2-ARYLSULFONYLIMINO-6-ALKYLPERHYDROPYRIDO[4,3-d]PIPERYMIDINE WITH POTENTIAL PHARMACOLOGICAL ACTIVITY.
12. STERICAL PREREQUISITES FOR PARTIAL ANTAGONISTS OF GLUTAMINERGIC GLUR5/6 RECEPTORS