In the recent years at the Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy, a number of 1-(1-arylimidazolidine-2-ylidene)-3-arylurea was synthesised. In many cases they exhibited analgesic activity. To find out the part of their structure that can be a possible analgesic ‘pharmacophor’, a series of new chain carbonyl derivatives of 1-aryl-2-iminoimidazolidine were synthesised.

   Based on the reports on the CNS (Central Nervous System) activity of some derivatives of 1-(aryl-2-iminoimidazolin-2-ylo)-3-arylnurea new derivatives were synthesised.

   Compounds with potential pharmacological activity 1-(1-arylimidazolidine-2-ylidene)-3-arylurea were obtained by condensation reaction of N-benzylcarbamic acid ethyl ester with appropriate 1-aryl-2-iminoimidazolidine.

The structure of all new compounds was confirmed by elementar analysis, as well by the ¹H NMR.

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