The aggregates of electrically neutral organic molecules are formed solely by hydrophobic lipophilic interaction (HLI) in water or aquiorgano mixtures. And we have found that the coaggregating tendencies of cholesterol esters and triglycerides might be one of the culprits of the arteriosclerosis. Therefore to find an organic molecules which can prevent or cure the arteriosclerosis would be very interesting and important. These molecules are called deaggregators (deAgr). We visualize that an effective deAgr might break up or reduce the size of aggregates.

We have searched and synthesized a variety compounds and quantitatively measured their deaggregating abilities, e.g. n-alkyl-glucopyranosides, n-alkyl-maltosides, phospholipids, saponins, dipeptides, phenols and phenol gemini compounds. The relationship between structure and the deaggregating ability is discussed. The results are consistent with the proposed hypothesis.

In this work the deaggregating abilities of the phenol and geminis compounds as shown were evaluated by following methodologies; (1) Fluorescence measurements. (2) Coaggregation experiment. (3) Aggregation number measurement. (4) Study on the restraint of cell conglutination

References:

[1] J. Chen, H. Yang, F. Yang, Z. W. Shen, X. J. Zhou, G. Z. Ji, Chinese J. Chem. 2005, 23, 1552.

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