Photolon is one of the new photosensitizers that found applications in photodynamic therapy (PDT). Its chemical structure has a partial reduced porphyrin moiety and molecular structure is comparable to chlorine e₆, which can be isolated after hydrolysis of the 5-membered exocyclic β-ketoester moiety of pheophorbide. For this study we have produced Photolon doped sol-gel matrix in form of films deposited on silica fibers cores. The matrix was produced from sols prepared from the silicate precursor TEOS mixed with ethyl alcohol. The sol-gel material was prepared with factor R=20, where R denotes the solvent to precursor molar ratio. Hydrochloride acid was added as catalyst in proportion to ensure the acid hydrolysis (pH»2). The mixture was stirred at room temperature for 4 hours by means of magnetic stirrer (speed 400 rot/min). The coated fibers were placed in various environments; liquid and gaseous, with various pH and with various zinc cations concentrations. The reactions were studied by exploiting spectroscopic methods, whereas the fluorescence response was examined. It was demonstrated that Photolon immobilized in sol-gel matrix may react with the environment and shows visible changes depending on the external changes. Furthermore, it was observed that these reactions are reversible. These biomaterials are also examined as carriers for PDT. It was proved that they posses bacteria toxic activity.

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