The Fe₃O₄ nanoparticles are prepared by hydrolyzing the co-solution of FeCl₃·6H₂O and FeCl₂·4H₂O with NH₄OH solution. Fe₃O₄/chitosan composite microspheres are prepared using the ionotropic gelation method by adding a proper amount of TPP solution to chitosan solution with Fe₃O₄ nanoparticles dispered in. The size of composite microspheres distribute between 0.1m to 1μm. This composite microsphere is magnetically responsive and biodegradable, and thus can be used as functional material or carrier for the delivery of drugs.

Key words: Fe₃O₄ nanoparticle；ionotropic gelation reaction；composite chitosan microsphere

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