The application of minimally invasive surgery for the treatment of coronary disease by the implantation of metallic "stents" has become a revolutionary technique with relatively good results against myocardial infarction.The use of biocompatible polymeric coatings offers a good way for the isolation of the metallic wall of the stent and the vascular medium, as well as a tool for the controlled release of specific drugs to improve the antithrombogenic character of the device and to control the restenotic process that is produced in a noticeable number of patiens at medium or long term. We work with new bioactive polymeric systems incorporating specific drugs with potent antiaggregating properties for platelets. Hydrophobic systems based on flexible alkyl acrylate copolymer systems present excellent adhesion to the surface of metallic stents, very high stability and good control of the delivery of the corresponding antiproliferative drug during several days to weeks depending on the application of the coating with a barrier layer of the same polymer system. The polymer coating offers good properties as support of antiproliferative compounds. Several well known drugs based on taxol, simvastatine, and rapamycin have been estudied and the release behaviour has been tested in vitro.

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