The sesquiterpene lactone Centipedolide A has been isolated from Centipeda minima (L.) A. Braun. & Aschers, a perennial herb which is commonly distributed in Siberia, Korea, China, India, Malaysia and Australia. In traditional Chinese medicine the herb is recommended as antiallergic, antitussive, and expectorant agent for the treatment of cold, nasal allergy and asthma. Structure elucidation and determination of the relative configuration of this new sesquiterpene lactone, Centipedolide A, has been accomplished by NMR spectroscopy and X-ray crystallography. The absolute configuration of Centipedolide A could be unambiguously established by a comparison of its experimental CD spectrum with that computed by time-dependent density functional theory .

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/7471 must be provided.

1. Cyclization of α-Diazonitriles to 5-Halo-1,2,3-triazoles. A Combined Experimental and Computational Study