Supramolecular reactions between crystalline materials or reactions between a crystalline material and a vapour can be used to generate new crystalline substances as well as crystal polymorphs, solvates, salts and co-crystals. These solvent-free processes can be exploited to prepare both hydrogen bonded co-crystals and coordination networks by non-solution solvent-free methods. Solid-vapour reactions do not differ from solid-gas uptake/release processes, and can also be used to prepare polymorphs and solvates. It is argued that solvent-less reactions involving molecular crystals represent a green route to supramolecular solid state chemistry and a viable alternative to solution methods for a thorough mapping of the "crystal space" (crystal reactivity, stability, vapour uptake/release, behaviour under mechanical stress, etc.). Examples will be provided in a broad range from organic molecular crystals, to coordination networks and salts.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/7288 must be provided.