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Making Crystals from Crystals: a Green Route to Crystal Engineering and Polymorphism

Dario Braga 

University of Bologna, Dipartimento di Chimica "G. Ciamician" (UNIBO), via Selmi 2, Bologna 40126, Italy


Supramolecular reactions between crystalline materials or reactions between a crystalline material and a vapour can be used to generate new crystalline substances as well as crystal polymorphs, solvates, salts and co-crystals. These solvent-free processes can be exploited to prepare both hydrogen bonded co-crystals and coordination networks by non-solution solvent-free methods. Solid-vapour reactions do not differ from solid-gas uptake/release processes, and can also be used to prepare polymorphs and solvates. It is argued that solvent-less reactions involving molecular crystals represent a green route to supramolecular solid state chemistry and a viable alternative to solution methods for a thorough mapping of the "crystal space" (crystal reactivity, stability, vapour uptake/release, behaviour under mechanical stress, etc.). Examples will be provided in a broad range from organic molecular crystals, to coordination networks and salts.


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Presentation: plenary lecture at 18th Conference on Physical Organic Chemistry, Plenary session, by Dario Braga
See On-line Journal of 18th Conference on Physical Organic Chemistry

Submitted: 2006-04-21 11:39
Revised:   2009-06-07 00:44