The present work describes synthesis of aryl- or heteroarylpiperazinyl derivatives of selected imides with constrain alkyl chain.

Last years studies shows that chain constraintion has significant influence on the serotonin receptors affinities [1, 2].

This work is continuation of our studies in searching of compounds with an anxiolytics and antidepressive activity.

New compounds were obtained by using cis- and trans-1,4-dichloro-2-butene and 1,2-bis(chloromethyl)benzene and amines: 1-(2-methoxyphenyl)piperazine, 1-(2-pyrimidyl)piperazine and selected imides:

The structures of all compounds were established by elementary and spectroscopic analysis.

1. A. J. Bojarski et al. J. Bioorg. Med. Chem. Lett. 14 (2004) 5863-6

2. A. J. Bojarski et al. Bioorg. & Med. Chem. Vol.14 Is.5 (2006) 1391-1402

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1. Microwave-assisted synthesis and antimicrobial activity of O-alkylamino derivatives of benzofurancarboxylic acids
2. Alkyl-nitroquipazine derivatives as serotonin transporter and 5-HT_1A receptor ligands
3. THEORETICAL STUDIES ON THE STERICAL PREREQUISITES FOR ACTIVE DOMAIN OF THE SEROTONERGIC 5-HT_1A RECEPTOR.
4. PRELIMINARY EVALUATION OF CNS EFFECTS OF ARYL- AND HETERO- ARYLPIPERAZINYL DERIVATIVES OF SELECTED ARRANGEMENTS AZATRICYCLOUNDECANE
5. SYNTHESIS OF A SERIES OF 3-PHENYL- PIPERIDINE-2,6-DIONE DERIVATIVES AS POTENTIAL ANXIOLYTICS
6. SYNTHESIS OF SOME N-SUBSTITUTED DE- RIVATIVES OF 1-(1H-PYRROLE-1-YL- METHYL) - 10-OXA-4-AZATRICYCLO- [5.2.1.0^2,6]DEC -8-ENE-3,5-DIONE WITH AN EXPECTED ANXIOLYTIC ACTIVITY