For many years isothiazoles are of interesting as a class of heteroaromatic compounds with pharmacological activity. One of them is Vratizolin, which has found, its use in medicine. Continuing our research on derivatives of isothiasole ring, diamide derivatives which showed antiviral, anticancer, antiinflamatory and immunosuppressive inspired our interest in the syntheses of new isothiazole compounds.

Starting material for this synthesis is 5-hydrazinoester. In the present research new series of 5-hydrazino substituted derivatives were obtained.

The project is financially supported by the Community of Wrocław Medical University GR-1311.

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