Figure 1. Cumulative release of idarubicin from biodegradable copolymers in a CFS observed for 356 days.

Figure 2. Cumulative release of idarubicin from biodegradable copolymer in saline and aCSF solutions observed for about 80 days.

From three types of copolymers the most stable idarubicin release for poly(glycolide-co-ε-caprolactone) with random chains is observed. No burst effect for all biodegradable aliphatic polyesters was confirmed. As expected, type of copolyesters, especially molar ratio of sequences and type of fluids amount of drug release and time of degradation were observed. Microstructure analysis of poly(glycolide-co-ε-caprolactone) matrices with idarubicin determined by ¹H NMR. Regular degradation rate by monitoring of such parameters as degree of randomness, average length of sequences and transestrification coefficient of the second mode were confirmed. Presence of idarubicin and metabolites in rat urine and serum weren't observed using NMR in vivo and HPLC measurements. Besides in urine change of glucose, glicine, alanine, histidine, lactate, acetate, citrate, succinate levels weren't also noticed. The result suggest that lack of systemic toxic effects of idarubicin device can be achieved using random poly(glycolide-co-ε-caprolactone) matrix with anthracycline. In this case side effects of chemiotherapy with idarubicin such as inflammation of gastrointestinal mucosa, nausea, chills and cardiotoxicity might be eliminated. In future bioresorbable copolyester devices with idarubicin could be effective and nontoxic therapy of brain gliomas used.

This study was supported by a grant (No. 3/FB/2004) from Foundation of Pharmacetical Sciences Development.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/6483 must be provided.

1. Study on the model of risperidone release from poly(L-lactide-co-glycolide) (85:15) matrices
2. Influence of structural and surface properties on the release of risperidone from poly(D,L-lactide-co-glycolide) (70:30) matrices
3. Effect of the degradation of poly(L-lactide-co-glycolide) (85:15) matrices containing risperidone on thermal and morphological properties
4. Degradation process of L-lactide/glycolide/trimethylene carbonate terpolymer in cell culture environment
5. Comparison of accelerated and real-time cyclosporine A release testing from poly(L-lactide-co-trimethylene carbonate) matrices
6. The influence of paclitaxel on hydrolytic degradation process in matrices obtained from aliphatic polyesters and polyestercarbonates
7. Laser ablation by MAPLE at cryogenic conditions to deposition of biodegradable polymer
8. LONG-TERM CYCLOSPORINE A (CyA) AND SIROLIMUS RELEASE FROM BIODEGRADABLE MATRICES AS A RESULT OF OPTIMAL ADJUSTMENT OF COPOLYMER CHAIN MICROSTRUCTURE
9. Elaboration and characterization of biodegradable scaffolds from poly(L-lactide-co-glycolide) copolymer synthesized with low-toxic zirconium acetylacetonate.