Running crystallizations in a robust manner is key for most end product and intermediate processes. However, in practice crystallization process design often omits a sound design of the process due to short term time limits. In this paper, we present an automated approach to design and run relative supersaturation control for the example of a cooling crystallization. A two step procedure is applied to run a supersaturation controlled crystallization, using an automated crystallizer with real time analysis of both solid and liquid phase. The aim of this paper is to underline that understanding and designing a robust crystallization process can be achieved rather rapidly when using an automated approach based on real time analytics.

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