The use of statins has been for many years connected with significant clinical benefits due to cholestrerol synthesis inhibition and increase of LDL - lipoprotein expression. In recent years, growing attention is being paid to the pleiotropic properties of statins. The mechanisms responsible for blocking prenylation of small G proteins are the underlying explanation of the above mentioned properties of statins. The existence of an interaction on the intracellular signalling level between the simulation of beta - adrenergic receptors and statin administration has been demostrated. The aim of the study was heart rate and blood pressure evaluation after metoprolol administration in rats given normal diet and simastatin for two weeks. The study was performed on Wistar outbred rats. After a two days adaptation period, simvastatin in a dose 10 mg/kg was administered into the stomach for a period of two weeks. The last administration drug was on the day prior to the heart rate and blood pressure of the tests. Heart rate and blood pressure measurements were performed with the use of HSE Haemodyn equipment. Before immobilization on the operating table, the rats were anaesthesized with the use of penthobarbital administered intraperitoneally in a dose of 30 mg/kg. Need be, general anaesthesia was sustained by one administration of penthobarbital (10 mg/kg of body mass dose), until complete lack of response to pain was achieved. After parameter stabilization (approximately 15 minutes), metoprolol in a dose of 1.0 mg/kg, and atropine in dose of 0.5 mg/kg were given intraperitoneally. After the administration of metoprolol and atropine, evalution of parametres was performed for another 15 minutes. Heart rate, systolic, diastolic and mean blood pressure inital were similar. After metoprolol and atropine administration, heart rate in rats receiving simvastatine was significantly decrease compared to rats without simvastatin. Blood pressure (systolic, diastolic, mean) values, after metoprolol and atropine administration in both groups, were statistically insignificant. It seems that the basis of the above mentioned interaction is the influence of simvastatin on the autonomic nervous system or modulation of intracellular transmission.

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1. THE INFLUENCE OF SIMVASTATIN IN HIGH DOSE AND DILTIAZEM ON MYOCARDIUM IN RABBITS