Search for content and authors
 

Medical applications of electrospun nanofibers

Tomasz Kowalczyk 

Polish Academy of Sciences, Institute of Fundamental Technological Research (IPPT PAN), Świętokrzyska 21, Warszawa 00-049, Poland

Abstract

Electrospinning is relatively simple and inexpensive method for preparation of  polymer nanomaterials with great potential of use in regenerative medicine and drug delivery systems. Such obtained materials were tested as a temporary scaffold for growing cells that reconstitute functional tissues and organs. The membranes made ​​of nanofibers have been used for in vivo experiments on reconstruction of the ureter and urinary bladder in an animal model - rat. Mesenchymal stem cells colonized the nanomaterial and proliferated on it better than on the acellular collagen matrix. The implant showed a high degree of neovascularization. Nanomaterial was hemostatic when used in kidney-sparing surgery procedures. used as a component of that after staining Fluorescently stained nanofibers made of serum albumin served as pH indicator of micrometer size. Wound dressings made of membrane containing albumin nanofibers had anti-adhesive properties and supported skin implants. Highly innovative prospect for the nanofibers is production of drug delivery systems. Release of antioxidant and protein growth factors was examined in vitro for the membranes made ​​of electrospun nanofibers. Nanofiber membranes used in neurology as an internal anti-cicatrisation dressing protected cerebral cortex and against neurodegeneration. Nanofibers releasing sodium glutamate were used to create an animal model of Lou Gehring’s Disease.

 

Legal notice
  • Legal notice:
 

Presentation: Invited Oral at Nano PL 2014, Symposium B, by Tomasz Kowalczyk
See On-line Journal of Nano PL 2014

Submitted: 2014-06-30 08:46
Revised:   2014-09-12 18:44