Electrospinning of polymer nanofibers is a versatile method of producing ultrafine fibers and has attracted large attention in the field of tissue engineering, wound healing and drug delivery systems. High surface area to volume ratio and similarity to Extracellular Matrix makes it potential for the use as a 3D scaffold as well as a drug delivery system. The aim of our work was to prepare active wound dressings for the prevention of excessive cicatrization after brain injury or spinal cord surgery. Traumatic Brain Injury (TBI) and its consequences are a serious public health problem. TBI can lead to pathological changes in the brain and glial scar formation which is an effective barrier preventing regeneration of damaged tissue. Produced in our laboratory electrospun mats composed of biodegradable polymer with medical approvals deliver drugs like: antioxidants – α-tocopherol and important in terms of regeneration of brain tissue NGF (Neural Growth Factor). Controlled release of these drugs can provide the supply of the appropriate medicine dose over a period of 8 to 14 days. It is found that dressing of surgically induced injury with nanofibrous mat did not induce inflammatory response but can promote correct healing process of the tissue. Construction of such system is a tedious experimental task. Hence, we take advantage of numerical simulation to construct a 3D finite element model which can help to optimize composition and geometrical structure of the nanofiber mat.

• Legal notice:
  

  Copyright (c) Pielaszek Research, all rights reserved.
  The above materials, including auxiliary resources, are subject to Publisher's copyright and the Author(s) intellectual rights. Without limiting Author(s) rights under respective Copyright Transfer Agreement, no part of the above documents may be reproduced without the express written permission of Pielaszek Research, the Publisher. Express permission from the Author(s) is required to use the above materials for academic purposes, such as lectures or scientific presentations.
  In every case, proper references including Author(s) name(s) and URL of this webpage: https://science24.com/paper/30259 must be provided.

1. Designing biosensors based on semiconductor nanoparticles for an early detection of neurodegenerative diseases.