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Nanofibrous mats as a protective materials in neurosurgery

Paweł Nakielski ,  Tomasz Kowalczyk ,  Tomasz A. Kowalewski 

Institute of Fundamental Technological Research, Polish Academy of Sciences (IPPT-PAN), Pawińskiego 5B, Warszawa 02-106, Poland


Electrospinning of polymer nanofibers is a versatile method of producing ultrafine fibers and has attracted large attention in the field of tissue engineering, wound healing and drug delivery systems. High surface area to volume ratio and similarity to Extracellular Matrix makes it potential for the use as a 3D scaffold as well as a drug delivery system. The aim of our work was to prepare active wound dressings for the prevention of excessive cicatrization after brain injury or spinal cord surgery. Traumatic Brain Injury (TBI) and its consequences are a serious public health problem. TBI can lead to pathological changes in the brain and glial scar formation which is an effective barrier preventing regeneration of damaged tissue. Produced in our laboratory electrospun mats composed of biodegradable polymer with medical approvals deliver drugs like: antioxidants – α-tocopherol and important in terms of regeneration of brain tissue NGF (Neural Growth Factor). Controlled release of these drugs can provide the supply of the appropriate medicine dose over a period of 8 to 14 days. It is found that dressing of surgically induced injury with nanofibrous mat did not induce inflammatory response but can promote correct healing process of the tissue. Construction of such system is a tedious experimental task. Hence, we take advantage of numerical simulation to construct a 3D finite element model which can help to optimize composition and geometrical structure of the nanofiber mat.


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Related papers

Presentation: Oral at Nano and Advanced Materials Workshop and Fair, by Paweł Nakielski
See On-line Journal of Nano and Advanced Materials Workshop and Fair

Submitted: 2013-06-29 13:48
Revised:   2013-06-29 13:48