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Coating anti-bacterial nanoparticles on flat and curved surfaces, and fighting resistant bacteria by employing the sonochemical method
Bar-Ilan University, Ramat-Gan 52900, Israel
Sonochemistry is an excellent technique to coat functional nanomaterials on various substrates, and imparting new properties to the substrates.
After a short demonstration of coating NPs on ceramics and stainless steel, I'll present the coating of textiles such as polyester, cotton, nylon, and nonwoven. In all cases a homogeneous coating of NPs was achieved. Silver is known for generations as antibacterial, and indeed the Ag NPs have killed the gram-negative E. Coli (strain 1313) as well as the gram-positive Staphylococus aureus (strain 195) bacteria very efficiently1. Lately, since the FDA shows less enthusiasm towards Ag we have moved to NPs of ZnO, CuO and MgO as antibacterial agents. They were coated on the above-mentioned fabrics and showed excellent antibacterial properties2. The coated textiles were examined for the changes in the mechanical strength of the fabric. A special attention was dedicated to the question whether the NPs are leaching off the fabric when washed repeatedly. Lately the coated ZnO NPs on cotton underwent 65 washing cycles at 92 0C in water in a Hospital washing machine, no NPs were found in the washing solution and an the antibacterial behavior was maintained. Our vision is that all the textiles in the Hospitals of the future will coated by antibacterial NPs.
We have demonstrated recently that we can fabricate NPs of salts (NaCl, CuSO4, KI, KBr) from their aqueous solution3. This work was continued and we have shown that in the same way we can produce organic nanoparticles (R6G, Anthracene, Polyaminopropyl Biguanide, Amylase, DNA, RNA) from their aqueous or from their solution in any other solvent. This study was continued to antibiotic compound such as gentamicin, tetracycline, ampicillin, and methicillin. We have prepared NPs of these four antibiotic materials from their aqueous solution. More importantly, these nanoparticles exhibit antibacterial activity, even against pathogens that are resistant to the antibiotic in its non-nanometric form.
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Presentation: Invited oral at Nano and Advanced Materials Workshop and Fair, by Aharon Gedanken
See On-line Journal of Nano and Advanced Materials Workshop and Fair
Submitted: 2013-04-02 07:54 Revised: 2013-12-03 18:31