The synthesis of pyrazoles is of great interest due to their wide applications in the pharmaceutical and agrochemical industry. Pyrazole derivatives are found to possess potent activities such as anti-inflammatory, anti-microbial, anti- HIV, anti-cancer, anti-allergic, anti-diabetic, cardiovascular and diuretic. The 1-phenyl-3-(propan-2-yl)-1H-pyrazol-5-ol was synthesized by using mixture of methyl-isobutylacetate and phenylhydrazine in methanol with the presence of a few drops of acetic acid as a catalyst. Light yellowish crystalline powder was obtained, which was further used to synthesize nano particles by water/oil micro-emulsion technique. In the present study, Triton X-100 was used as surfactant and n-heptane was used as oil phase. The single phase region was determined. The solution 1-phenyl-3-(propan-2-yl)-1H-pyrazol-5-ol in chloroform was added in a drop-wise manner under constant stirring to synthesize nano particles. The powder XRD study suggested triclinic structure with characteristic peak broadening indicating the nano structured nature having average particle size 33 nm obtained by using Scherrer’s formula. The TEM study indicated nearly spherical nano-particles having diameter varied from 11 nm – 42 nm. The nanoparticles were also characterized by FT – IR spectroscopy and mass spectroscopy. From the FTIR study the functional groups C-H, C=C, =N-N- and –C=O were confirmed. The thermal stability of the nano particle was studied by using TG-DTA-DSC. The nano particles remained thermally stable up to 168^oC after that it started decomposing. Thermodynamic and kinetic parameters were calculated by using Coats-Redfern relation to the thermo-gram. Results are discussed.

1. PRESENTATION: Synthesis and characterization of 1-phenyl-3-(propan-2-yl)-1H-pyrazol-5-ol nano particles by using w/o microemulsion technique, Microsoft Office Document, 0MB

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